Studies on sphingosine. by Mary Joyce Murray

Cover of: Studies on sphingosine. | Mary Joyce Murray

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Thesis (M.A.) -- University of Toronto, 1947.

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Sphingosine (2-aminotrans-octadecene-1,3-diol) is an carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.

Studies with intact cells (Wilson et al., ) and isolated rat liver plasma membranes (Slife et al., ) found that endogenous sphingolipids are hydrolyzed to free sphingosine, in the latter case via turnover of sphingomyelin by a Mg 2 +-dependent sphingomyelinase and ceramidase.

What factors determine the extent to which ceramides are. Sphingosine 1-phosphate (SPP) is a sphingolipid metabolite that has been shown to affect diverse biologic processes including cell proliferation, survival, motility, and differentiation.

1,2 SPP is capable of acting intracellu-larly as a second messenger in mitogenic signaling by platelet-derived growth factor 3 and in calcium release in. Sphingosine is a sphingenine in which the double bond is trans.

Studies on sphingosine. book has a role as a human metabolite and a mouse metabolite. It is a conjugate base of a sphingosine (1+). It is an enantiomer of a L-erythro-sphingosine.

An amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of. The potent lipid mediator sphingosinephosphate (S1P) is produced inside cells by two closely related kinases, sphingosine kinase 1 (SPHK1) and SPHK2, and has emerged as a crucial regulator of immunity.

Many of the actions of S1P in innate and adaptive. Recent studies show that bioactive lipids are important regulators for stem cell survival and differentiation. The sphingolipid ceramide and its derivative, sphingosinephosphate (S1P), can act synergistically on embryonic stem (ES) cell differentiation.

Structure–Activity Relationship Studies of Sphingosine Kinase Inhibitors and Mitochondrial Uncouplers Elizabeth S. Childress Dissertation submitted to the faculty of the Virginia Polytechnic Institute and State University in partial fulfillment of the requirements for the degree of Doctor of Philosophy In Chemistry.

Sphingosinephosphate (S1P) is a signaling sphingolipid, also known as lysosphingolipid. It is also referred to as a bioactive lipid mediator. It is also referred to as a bioactive lipid mediator.

Sphingolipids at large form a class of lipids characterized by a particular aliphatic aminoalcohol, which is sphingosine. Mehling M(1), Johnson TA, Antel J, Kappos L, Bar-Or A.

Author information: (1)Department of Neurology, University Hospital, Basel, Switzerland. The oral sphingosine 1-phosphate (S1P) receptor (S1PR) modulator fingolimod has been shown to be effective in the treatment of patients with relapsing.

Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In Studies on sphingosine. book, S1P is secreted into the extracellular environment and signals via.

Ensembl ENSG ENSMUSG UniProt O Q8R0X7 RefSeq (mRNA) NM_ NM_ NM_ NM_ RefSeq (protein) NP_ NP_ NP_ NP_ Location (UCSC) Chr – Mb Chr – Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Sphingosine-1. Studies on the sphingosines and Garner’s aldehyde have prompted us to investigate sphingosine-related metabolites such as myriocin, the mycestericins, or the sphingofungins.

Many of these metabolites bear an -substituted serine moiety as a common feature, and the. THE STRUCTURE OF SPHINGOSINE” Sirs: Levene and West.

have suggested that sphingosine is l-amino- 2,3-dihydroxyheptadecene Klenk and Diebold, as a result of later studies, revised this formula to 1,2-dihydroxyaminoocta- decene The data of the latter authors establish conclusively that sphingosine has a Cl8 chain, a double bond between.

Synthesis of Sphingosine and the Ceramides. The sphingolipids, like the phospholipids, are composed of a polar head group and two nonpolar core of sphingolipids is the long-chain amino alcohol, sphingosine.

The sphingolipids include the sphingomyelins and glycosphingolipids (the cerebrosides, sulfatides, globosides and gangliosides). Biological Activity Endogenous second messenger involved in the control of cell proliferation and motility, and Ca 2+ mobilization.

Acts as an agonist at sphingosinephosphate receptors (S1P ) and as an activator of GPR3, GPR6 and GPREffectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.

Sphingosine: Product suppliers. View disclaimer. Sponsored products disclaimer. Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

The Hooks laboratory studies the molecular mechanisms by which cellular signaling regulates cell function, and how these signaling mechanisms go awry in cancer and central nervous system disorders. Specifically, we study G-protein signaling cascades and their dynamic regulation by activating receptors and deactivating RGS proteins (Regulator of.

Moreover, some studies showed that adenomas and cancers have higher expression levels of sphingosine kinase 1, which is responsible for the conversion.

Sphingosine definition is - a long-chain unsaturated amino alcohol C18H37O2N that is found especially in cell membranes and is a primary constituent of sphingolipids. Sphinganine is a blocker postlysosomal cholesterol transport by inhibition of low-density lipoprotein-induced esterification of cholesterol and cause unesterified cholesterol to accumulate in perinuclear vesicles.

It has been suggested the possibility that endogenous sphinganine may inhibit cholesterol transport in Niemann-Pick Type C (NPC) disease. (PMID: About this book. Sphingosinephosphate is a bioactive lysophospholipid which has become, in recent years, the focus of much research interest as it has widespread developmental and physio-pathological actions, controlling events within the nervous, reproductive, gastrointestinal, vascular, respiratory, and immune systems, in addition to having a prominent role in cancer, early.

Define sphingosine. sphingosine synonyms, sphingosine pronunciation, sphingosine translation, English dictionary definition of sphingosine. A basic, long-chain, unsaturated amino alcohol, C18H37NO2, that combines with lipids to form sphingolipids.

n biochem a. Sphingosine 1 phosphate (S1P) is a bioactive lipid that regulates cellular activity, including proliferation, cytoskeletal organization, migration, and fibrosis. In this study, the potential relevance of S1P–Rho signaling in pterygium formation and the effects of ultraviolet (UV) irradiation on activation of the S1P/S1P receptor axis and fibrotic responses were investigated.

sphingosine[′sfiŋgə‚sēn] (biochemistry) C18H37O2N A moiety of sphingomyelin, cerebrosides, and certain other phosphatides. Sphingosine an unsaturated higher aliphatic amino alcohol, C13H27CH=CHCH(OH)CH(NH2)CH2OH.

Sphingosine is soluble in organic solvents and insoluble in water; its melting point is °–83°C, and its properties are those. The new facility will enhance space for GMP production of the company's development-stage clinical candidates, including Enzo's proprietary sphingosine kinase 1 inhibitor, SK1-I, which is being investigated for potential applications in oncology and autoimmune diseases.

Biomolecules, an international, peer-reviewed Open Access journal. Dear Colleagues, Despite the exciting recent advances in techniques and the remarkable progress in the field, sphingolipids, termed after the mythological sphinx, still remain enigmatic because of their unprecedented complexity and their function both as membrane components and bioactive molecules.

Brinkmann V () Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther – PubMed Google Scholar Brinkmann V () FTY (fingolimod) in multiple Sclerosis: therapeutic effects in the immune and the central nervous system.

Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung Saad Sammani, Liliana Moreno-Vinasco, Tamara Mirzapoiazova, Patrick A.

Singleton, Eddie T. Chiang, Carrie L. Evenoski, Ting Wang, Biji Mathew, Aliya Husain, Jaideep Moitra, Xiaoguang Sun, Luis Nunez, Jeffrey R.

Jacobson, Steven M. Associate ProfessorDepartment of SurgeryGainesville, FL Education MBBS, MR Medical College, Gulbarga, India () PhD, University of Virginia, Charlottesville, VA () Academic Appointments Associate Professor, Department of Surgery, University of Florida, Gainesville, FL (present)Assistant Professor, Department of Surgery, University of Virginia.

S1P metabolism. S1P is present at submicromolar concentrations in various biological fluids and tissues [].It is predominantly present in the platelets and erythrocytes in the blood, at concentrations of nM to 4 μM [], because the platelets lack the S1P degradation enzyme SPL [].Human serum is also a rich source of S1P with concentrations ranging from nM to 1 μM.

Inthe crystal structure of apolipoprotein M (apoM) and its capacity to bind sphingosinephosphate (S1P) was characterized. Since then, a variety of studies has increased our knowledge on apoM biology and functionality.

From being an unknown and hardly significant player in overall metabolism, apoM has gained significant interest. Packaging 1 mg in glass bottle Biochem/physiol Actions A lipid second messenger that binds to S1P 1 and S1P 3 receptors.

Mobilizes intracellular Ca 2+ stores and decreases cellular cAMP. Activates phospholipase D. S1P stimulates the migration of endothelial cells but inhibits the migration of other cell types. Title: The Ligand Binding Region of the Sigma-1 Receptor: Studies Utilizing Photoaffinity Probes, Sphingosine and N-Alkylamines VOLUME: 18 ISSUE: 7 Author(s):Arnold E.

Ruoho, Uyen B. Chu, Subramaniam Ramachandran, Dominique Fontanilla, Timur Mavlyutov and Abdol R. Hajipour Affiliation:Department of Neuroscience and the UW Eye Research Institute, University of.

Thus, it is likely that activation of sphingosine kinase is a critical event in the signaling cascades initiated at FcϵRI. In sum, these studies provide new insights into the biological functions of intracellularly generated SPP and emphasize the importance of sphingosine kinase, the enzyme that regulates its formation.

Search the world's information, including webpages, images, videos and more. Google has many special features to help you find exactly what you're looking for. chronic toxicology studies in rats and dogs • Sphingosinephosphate (S1P) – a membrane-derived lysophospholipid signaling Preclinical Safety Assessment of Etrasimod (APD), an Oral Sphingosine Phosphate Receptor (S1P) Modulator with a Favorable Profile.

Sphingosinephosphate (S1P), a zwitterionic sphingolipid, is an important cellular metabolite and signalling lipid in animal cells. It has also been found in insects, yeasts and plants.

You can find additional information on S1P at the following link: LIPID MAPS Lipidomics Gateway. Light Sensitive. Molecular Formula. C 18 H 38 NO 5 P. The reaction product, sphingosinephosphate (SPP), was considered for more than 20 yr to be merely an intermediate in the catabolism of long-chain sphingoid bases to palmitaldehyde and phosphoethanolamine (3, 10).

Studies in our lab stimulated new interest in the potential roles of SPP as a second messenger. (biochemistry) An unsaturated aliphatic amino alcohol associated with the lipids of brain tissue. Abstract. The sphingolipids are a class of compounds quite analogous to the lipid series derived from glycerol.

Just as glycerol can form a series of phosphorous containing complex lipids, i. e., lecithin, cephalin, etc.

(cf. chap, by Rossiter, p. 93), sphingosine can combine with fatty acids, phosphorous, and bases to give rise to the sphingomyelins. Universal Intracellular Roles of Sphingosine 1-Phosphate: from Plants to Higher Eukaryotes. Recent studies indicate that S1P, known to be important for calcium regulation in animal cells, is also involved in calcium-dependent signaling of calcineurin in yeast and in the plant A.

thaliana.Sphingosinephosphate and the Rgs Rhogefs Regulate Vascular Smooth Muscle Phenotype. Given previous studies on the interaction of Gα12/13 with the RGS subfamily of RhoGEFs (LARG, PRG, P), we hypothesized that one or more of these RhoA activators was important in S1P-mediated SMC differentiation.

Scholarly Articles and Book. Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes including proliferation, survival, and migration, as well as angiogenesis and allergic responses.

S1P levels inside cells are tightly regulated by the balance between its synthesis by sphingosine kinases and degradation. S1P is interconvertible with .

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